Complication strategies are an integral part of the field of interventional cardiology. There are multiple components to the strategies. They include the identification of patients and lesions in whom increased complication rates may be anticipated. For this group of strategies, great care is required for planning optimal approaches in these complex situations. Another group of strategies relates to situations where an unanticipated complication occurs. For such strategies, it is important — indeed, imperative — to have a toolbox of Plan B options that can be used to mitigate the clinical problem. For these unanticipated complications, several important considerations must be kept in mind.